Monomer. Homodimer. Interacts with COPS5 and SNCA.
Function:
Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.
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Precision
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Recovery
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Linearity
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References
1.
"Cloning and expression of ubiquitin carboxyl-terminal hydrolase in pig." Tian X.
,
Li J.
,
Chen Y.
Submitted (2003-11) to the EMBL/GenBank/DDBJ databases
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Cited for: NUCLEOTIDE SEQUENCE [MRNA]